2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen.

Pharmacodynamics

2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein.

2-Hydroxysaclofen has been reported to be more potent than saclofen.

See also

  • Saclofen - another GABAB receptor antagonist
  • Baclofen - an agonist of the receptor

References


HEXACYL® Tropfen Produkte

Schema of the synthesis of 2hydroxyN(2hydroxyphenyl)[1,213

Effects of picrotoxin and a high dose of 2hydroxysaclofen coinjected

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